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BELANGRIJK: HOE DEZE INFORMATIE TE GEBRUIKEN: Dit is een samenvatting en bevat NIET alle mogelijke informatie over dit product. Deze informatie garandeert niet dat dit product veilig, effectief of geschikt voor u is. Deze informatie is geen individueel medisch advies en vervangt het advies van uw zorgverlener niet. Vraag uw zorgverlener altijd om volledige informatie over dit product en uw specifieke gezondheidsbehoeften.

  • PRAMIPEXOLE – ORAL (pram-ih-PEX-ole)


Pramipexole is used alone or with other medications to treat Parkinson’s disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move (“on-off syndrome”).

This medication is also used to treat a certain medical condition (restless legs syndrome – RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep.

Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.


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Read the Patient Information Leaflet provided by your pharmacist before you start taking pramipexole and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

  1. Nemen

    Take this medication by mouth with or without food, as directed by your doctor. Taking this medication with food may reduce nausea. To decrease the risk of side effects (e.g., drowsiness, low blood pressure) when you first start taking pramipexole, your doctor will slowly increase your dosage until the best dose for you is reached. Take this medication as prescribed. Do not increase your dose or take it more often than directed.

  2. Gebruik dit medicijn regelmatig

    Gebruik dit medicijn regelmatig om er het meeste profijt van te hebben. Om u te helpen herinneren, neemt u het elke dag op hetzelfde tijdstip in.

  3. Inname van dit medicijn

    If you stop taking this medication for several days, you may need to increase your dose slowly back to your previous dosage. Talk with your doctor about how to restart the medication. Do not stop taking this medication without your doctor's approval. Although very unlikely, if you suddenly stop taking this drug, withdrawal reactions may occur. Such reactions can include fever, muscle stiffness, and confusion. Report any such reactions to your doctor immediately. If you have Parkinson's disease and are stopping regular treatment with this drug, gradually reducing the dosage as directed will help prevent withdrawal reactions. Consult your doctor or pharmacist for more details.

  4. Dosering

    De dosering is gebaseerd op uw medische toestand en reactie op de behandeling.

  5. Arts

    It may take a few weeks for the full effects of this medication to be noticed. Inform your doctor if your symptoms do not improve or if they worsen.


  • Nausea
  • duizeligheid
  • slaperigheid
  • trouble sleeping
  • constipation
  • hoofdpijn
  • or dry mouth may occur

If these effects persist or worsen, notify your doctor promptly.

Denk eraan dat uw arts dit medicijn heeft voorgeschreven omdat hij of zij heeft geoordeeld dat het voordeel voor u groter is dan het risico op bijwerkingen. Veel mensen die dit medicijn gebruiken, hebben geen ernstige bijwerkingen.

Vertel het uw arts onmiddellijk als een van deze onwaarschijnlijke maar ernstige bijwerkingen optreedt:

  • flauwvallen
  • mental/mood changes (e.g., confusion, depression, hallucinations, memory problems)
  • increased difficulty moving/walking
  • muscle cramps/spasm
  • rusteloosheid
  • decreased sexual ability
  • increased shakiness (tremor)/stiffness

Tell your doctor immediately if any of these rare but very serious side effects occur:

  • swelling of the ankles/feet
  • chest pain
  • compulsive behaviors (e.g., pathological gambling)
  • fever
  • unusually fast/slow/irregular heartbeat
  • muscle pain/weakness
  • unusual tiredness
  • change in amount of urine
  • vision changes

Some people taking pramipexole have reported falling asleep suddenly during their usual daily activities (e.g., talking on the phone, driving). In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur any time during treatment with pramipexole, including up to 1 year after starting the medication. Therefore, you should not drive or take part in other possibly dangerous activities until you are certain that this medication will not cause drowsiness or sudden sleep. If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor. Your risk is increased with use of alcohol or other medications that can make you drowsy. You may also develop a sudden drop in blood pressure, which can cause dizziness, nausea, sweating, and fainting. This is more likely when you are first starting the medication, when your dose is increased, or when you get up suddenly. To lower your risk, get up slowly from a sitting or lying position.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

  • uitslag
  • jeuk/zwelling (vooral van het gezicht/tong/keel)
  • ernstige duizeligheid
  • moeite met ademhalen

Dit is geen volledige lijst van mogelijke bijwerkingen. Als u andere effecten bemerkt die hierboven niet zijn vermeld, neem dan contact op met uw arts of apotheker.

In het VK – Bel uw arts voor medisch advies over bijwerkingen.


Before taking pramipexole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

  1. Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure, heart problems (e.g., irregular heartbeat, heart failure), kidney problems, mental/mood disorders (e.g., confusion, hallucinations, psychosis, schizophrenia), sleep disorder (e.g., sleep apnea, narcolepsy).
  2. Dit medicijn kan u duizelig of slaperig maken. Rijd niet, gebruik geen machines en voer geen activiteiten uit waarvoor alertheid vereist is totdat u zeker weet dat u dergelijke activiteiten veilig kunt uitvoeren. Beperk alcoholische dranken.
  3. To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
  4. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at a greater risk for side effects such as dizziness and hallucinations while using this drug.
  5. Tijdens de zwangerschap mag dit medicijn alleen worden gebruikt als dit duidelijk nodig is. Bespreek de risico's en voordelen met uw arts.

This drug may pass into breast milk and could have undesirable effects on a nursing infant. It may also affect milk production. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.


Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

  • antipsychotics (e.g., chlorpromazine, haloperidol, thiothixene)
  • cimetidine
  • metoclopramide

If you are taking levodopa or a carbidopa/levodopa combination, your doctor may direct you to decrease your levodopa dose after you start taking pramipexole.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., risperidone, amitriptyline, trazodone).

Check the labels on non-prescription medications for heartburn/upset stomach. They may contain cimetidine, which can affect the level of pramipexole in your body. Also check the labels on all your medicines (e.g., allergy, cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

Dit document bevat niet alle mogelijke interacties. Vertel uw arts of apotheker daarom voordat u dit product gebruikt alle producten die u gebruikt. Houd een lijst van al uw medicijnen bij u en deel de lijst met uw arts en apotheker.


If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline. Canadian residents should call their local poison control center directly.

OPMERKINGEN: Deel dit medicijn niet met anderen.

People with Parkinson’s disease may have an increased risk for developing skin cancer (melanoma). If you are taking this drug to treat Parkinson’s disease, tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams.


If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
  • Houd alle medicijnen uit de buurt van kinderen en huisdieren.
  • Spoel medicijnen niet door het toilet of giet ze niet in een afvoer, tenzij u hierom wordt gevraagd.
  • Gooi dit product op de juiste manier weg wanneer het is verlopen of niet langer nodig is.

Raadpleeg uw apotheker of plaatselijk afvalverwerkingsbedrijf voor meer informatie over het veilig weggooien van uw product.

nl_BENederlands (België)